Product name: S-adenosyl methionine

Biochemistry and pharmacology of S-adenosyl methionine:
S-denosyl methionine(SAM), a biological compound participating in methyl group transfer, is present in all living cells. It issynthesized endogenously from adenosine triphosphate(ATP)and methionine adenosyltransferase.

Transmethylation, transsulfuration and aminopropylation are the metabolic pathways that use SAM. Although these anabolic reactions occur throughout the body, most SAM is produced and consumed in the liver. The activated methyl group(CH3)in SAM allows donation of this group to an acceptor substrate in transmethylation reactions.

More than 40 metabolic reactions involve the transfer of a methyl group of SAM to various substrates such as nucleic acids, proteins and lipids.

Therapeutic Uses of SAM:
SAM can help fight depression, liver disease, and the pain of osteoarthritis. In the United States SAM is sold as nutritional supplement under the marketing name SAM-e.

A body of studies has been published, mostly in Europe and America, evaluating the medical and nutritional roles of SAM. These studies have demonstrated that SAM has multiple medicinal applications. In Europe, SAM has been used clinically for more than twenty years in the treatment of a number of medical conditions, such as depression, liver disease and arthritis. Long-term clinic studies on SAM have revealed its significant effect in treating depression. SAM helps support the incorporation of sulfate groups into proteoglycans which osteoarthritis. Since it play a critical role in the synthesis of polyamines and provides cysteine for the production of glutathiones(GSH), the major endogenous hepattoprotective agent, SAM demonstrates a protective effect in the treatment of liver diseases, such as cancer chemotherapy-induced liver toxicity and other liver dysfunctions. As an important healthcare dietary supplement and an antidepressant drug, SAM prossesses a large market in Europe and America. SAM, as an antidepressant drug, has many obvious advantages: Fewer side effects than traditional drugs which often result in weight gain, sexual dysfunction, insomnia, drug sensitivity, and other side effects; More rapid effect than traditional drugs which function at least six weeks after oral supplement whereas the former functions obviously only one week after being taken in.

SAM has a already become a mainstream natural supplement, especially after the Dietary Supplement Health and Education Act was passed in 1999. This law allowed the distribution of SAM as an over-the-counter supplement.